To further illustrate this idea of bacterial connection to a specific illness, a study was done on wild mice where they introduced one foreign bacteria called H. Helmiticus. This caused irritable bowel disease in the mice and an increase of an inflammatory chemical, IL 17. They then introduced another bacteria, B. Fragilis which neutralized the H. Helmiticus and increased an anti-inflammatory chemical IL 10, which suppressed the IBD and IL 17.
Professor Alan Ebringer in the U.K. has found that there is a strong Rheumatoid Arthritis (R.A.) connection to Proteus Mirabilis in the upper urinary tract. His group has done ground breaking work on establishing specific amino acid patterns of between the Proteus hemolysin and R.A. associated HLA-DR molecules as well as the Proteus urease enzyme and hyaline cartilage (a specific collagen found in the small joints). What this means is that they have found molecular mimicry between the Proteus bacteria and a type of HLA (human leukocyte antigen) that is on the surface of small joints. This results in an autoimmune trigger when an infection of Proteus occurs. The body attacks the joints thinking it is attacking Proteus.
Diagnostic Solutions Laboratory
In the past year, I switched from a well-respected lab doing microscopic stool testing to PCR testing done by Diagnostic Solutions Laboratory. In addition to the PCR testing they do, they have several intestinal health tests that give added information to enhance their reports:
Elastase-1: This is a digestion marker for enzymatic breakdown of proteins.
Steatocrit: This is a digestion marker for fat.
Calprotectin:This is a marker for colonic inflammation. The resulting score can differentiate between irritable bowel syndrome (I.B.S.) and irritable bowel disease (I.B.D.)
Secretory IgA: Is an antibody protein that helps maintain barrier protection. It increases in an acute infection and lessens with chronic infections and stress.
Anti-Gliadin IgA: A marker for gluten sensitivity in the stool that is more sensitive than blood antibodies.
b-Glucuronidase: A chemical given off by certain species of bacteria. It is also found to be elevated by 1.7 times in those with colon cancer. It also interferes with a detox pathway that breaks down estrogen. This can result in elevations in estrogen and an increased likelihood of estrogen dependent cancers.
Zonulin: Is a protein that prevents permeability of the intestinal barrier cells. Elevated zonulin is a sign of “leaky gut syndrome”.
If you would like to see a sample report from their lab click here
If you think you or someone you know would benefit from having this test done, please let me know and stool kits can be picked up at my office. The price for the test depends on insurance coverage, and can vary depending on the tests that are chosen to be performed. I can discuss this with you by phone or email.