What is the problem?
Sugar consumption – 160 lbs. per year
Wheat consumption – 146 lbs. per year. Non celiac gluten sensitivity affects about 14% of the U.S. or about one billion people worldwide.
Pesticide exposure – Glyphosate and celiac disease have risen in tandem since the 1970’s.
Caloric sweeteners – 142 lbs. per year
Eighty-seven percent rise in vegetable oils since 1970, 30% increase in simple carbohydrate consumption since 1965, a decrease in fat intake by 25%.
Rise in diabesity and food allergies 90% of sensitivities are either milk, soy, eggs, wheat, peanuts, tree nuts, and shellfish.
Medications – 35 million lbs. of antibiotics produced each year, 80% given to livestock. The CDC says 30% of antibiotic prescriptions are unnecessary. They deplete B vitamins and upset the natural microbiome of our gut.
Toxins/Stress Triclosan, a common toothpaste ingredient causes gut inflammation, is associated with IBS and colitis and colon cancer.
Bacterial toxins: LPS – lipopolysaccharides – Commonly a toxin from gram negative bacteria damages mitochondria and increases inflammatory cytokines causing damage to the gut lining. It is associated with systemic inflammation of joints and organs and may play a role in the exacerbation of autoimmune diseases. It also causes an increased sensitivity to pain. Cytolethal distending toxin B (CdtB) released by E. coli, salmonella, shigella, and Campylobacteria jejuni, is eleven times more inflammatory than LPS and capable of creating extreme inflammatory responses systemically in the body.
Pathogenic microbes – for example Klebsiella pneumonia. This bacterium is associated with reactive arthritis. In genetically susceptible people they might have a genetic positive test for HLA-B27 and have higher levels of IgG antibodies to Klebsiella and this could result in ankylosing spondylitis. Bacteria produced D-Lactic acid is a neurotoxin and it causes muscle pain and confusion. These bacteria produce tryptophanase an enzyme that leads to tryptophan and serotonin/melatonin deficiency and increased neurodegenerative disease.
Diagnosis of leaky gut syndrome
Zonulin: Is a protein found between the cells of the intestinal tract. Elevated levels indicate a breakdown of the protective barrier. It is also associated with autoimmune diseases, celiac disease, rheumatoid arthritis, type 1 diabetes, adult glucose intolerance, asthma, and M.S.
Actomysin IgA: is also associated with celiac disease, IBD, IBS, and SIBO
Occludin/Zonulin IgG, IgA, IgM, becomes elevated with stress, and excessive NSAID use.
Lipopolysaccharides IgG, IgA, IgM
Diagnosis of Joint Autoimmunity
Arthritic Peptide: Associated with mixed connective tissue disease, Rheumatoid Arthritis, and Osteoarthritis
Collagen antibody: Lupus, Arthritis
Fibulin antibody: Associated with Osteoarthritis
MMP-1 and MMP-9: expression of these markers would indicate a degrading of type 1 and 3 collagen.
In all the above it is possible to have non-celiac gluten sensitivity which mimics all the same symptoms of celiac disease. The most common are abdominal pain, constipation, diarrhea, and gas. What is less obvious is symptoms such as anemia, anxiety, arthralgia (joint pain), ataxia (unsteady gait), depression, rashes, fatigue, headaches, irritability, myalgias (muscle pain), and peripheral neuropathy. People with thyroid problems are often a result of this sensitivity because the two most common sensitivities gluten and casein bind readily to thyroid tissue in what scientists call molecular mimicry triggering thyroid antibodies that then attack the thyroid.